Exhibit 150 · Registry analysis
Trends in cancer incidence and mortality rates in early-onset and older-onset age groups in the United States, 2010–2019
Out of 33 cancer types occurring among 15-49-year-olds considered in this analysis, fourteen cancer types had significantly increasing incidence rates in the most recent time period in at least one early onset age group, and 18 cancer types had significantly decreasing incidence rates
NCI researchers estimated US cancer incidence for 2010–2019 and mortality for 2010–2022 across 33 cancer types. Incidence rose for 14 types in at least one early-onset age group (15–29, 30–39 or 40–49) and fell for 18. The largest absolute increases in 2019 over the numbers expected from 2010 rates were in female breast (4,834 additional cancers), colorectal (2,099), kidney (1,793) and uterine cancer (1,209). Mortality did not rise for most cancers; colorectal, uterine and testicular cancer mortality rose in early-onset groups. The authors wrote that the drivers could include established and new causes and increased detection. The databases held no risk-factor data.
- Source
- Meredith S. Shiels et al., National Cancer Institute; Cancer Discovery
- Date
- 8 May 2025 (online)
- Quoted from
- Results, "Overall trends in early onset cancer incidence rates" (author manuscript text via NCBI PMC, PMC12226221)
- Grade
- Peer-reviewed
- Document
- https://doi.org/10.1158/2159-8290.CD-24-1678
- Accessed
- 2026-11-09
- Cited by
- Findings citing this exhibit
- Note
- The count of 33 types and the absence of risk-factor data come from the NIH release and its coverage.