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Exhibit 109

The vacuolating virus, S.V.40

Exhibit 109 · Research article

The vacuolating virus, S.V.40

Vacuolating virus strains S207, S211 and S215 were derived from types 1, 2 and 3, respectively, of Dr. Albert Sabin’s live attenuated poliomyelitis vaccine.

Merck researchers isolated and named simian virus 40, a vacuolating virus present in the rhesus monkey kidney cell cultures used to make polio vaccine. Several of their isolates came from seed strains of Sabin's live oral polio vaccine.

Source
Ben H. Sweet and Maurice R. Hilleman, Merck Institute for Therapeutic Research; Proceedings of the Society for Experimental Biology and Medicine 105:420–427
Date
November 1960
Quoted from
Sweet & Hilleman, Proc Soc Exp Biol Med 105:420-427 (1960), Results, 'Recovery of strains of vacuolating virus', p. 421 (Table I)
Grade
Peer-reviewed
Document
https://doi.org/10.3181/00379727-105-26128
Accessed
2026-11-09
Cited by
Findings citing this exhibit
Note
The article itself was not opened; citation and description come from bibliographic records and the IOM report's attribution.

Cited by

Finding MED-7.2
Reported Federal officials knew by 1960 that polio vaccine carried SV40. They ordered new lots screened in 1961, recalled no existing stock, and certified every lot free of the virus only from 1963.