The Lacuna Project

lacuna (n.) a gap in a record where something should be

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Exhibit 093

Response from the authors of the original Study 329

Exhibit 093 ยท Correspondence

Response from the authors of the original Study 329

The original investigators stated that the secondary measures were added before the blind was broken, by the academic authors, because the original depression scale measured adolescents' symptoms poorly; that their article distinguished negative primary outcomes from favorable secondary results; and that the reanalysis was biased and its RIAT method undocumented.

Source
Keller et al., BMJ rapid response
Date
2015
Grade
Reported
Document
https://www.bmj.com/content/351/bmj.h4320/rr-27
Accessed
2026-11-09
Cited by
Findings citing this exhibit
Note
Full BMJ rapid-response page (rr-27). Wording as reported in the secondary copy: These secondary outcomes were clearly reported as separate from the negative primary outcomes.

Cited by

Finding MED-4.2
Peer-reviewed A 2001 article reported paroxetine effective and well tolerated in depressed adolescents. A 2015 reanalysis of the same trial's records found no advantage over placebo on the prespecified outcomes and counted 11 paroxetine patients with suicidal or self-injurious behavior where the article had counted five.