The Lacuna Project

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Exhibit 017

Association of BCG, DTP, and measles vaccines with all-cause mortality in children: systematic review

Exhibit 017 · Systematic review

Association of BCG, DTP, and measles vaccines with all-cause mortality in children: systematic review

Although efforts should be made to ensure that all children are immunised on schedule with BCG, DTP, and MCV, randomised trials are needed to compare the effects of different sequences.

BCG and measles vaccines were associated with lower all-cause mortality. DTP was associated with a pooled relative risk of 1.38 (95% CI 0.92–2.08) from ten studies, all at high risk of bias. Recommended randomized trials of vaccine sequence; recommended no change to the schedule.

Source
Higgins et al., BMJ (commissioned by WHO SAGE)
Date
2016
Quoted from
BMJ 2016;355:i5170, abstract, Conclusions
Grade
Peer-reviewed
Document
https://pubmed.ncbi.nlm.nih.gov/27737834/
Accessed
2026-11-09
Cited by
Findings citing this exhibit

Cited by

Finding MED-3.7
Open question Studies of 1980s data from Guinea-Bissau found higher infant mortality after DTP vaccination, and no randomized trial has tested the finding.