The Lacuna Project

lacuna (n.) a gap in a record where something should be

Independent research. Not affiliated with any government, agency, or company.

Exhibit 210

Adenocarcinoma of the Vagina: Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young Women

Exhibit 210 ยท Case-control study

Adenocarcinoma of the Vagina: Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young Women

Most significantly, seven of the eight mothers of patients with carcinoma had been treated with diethylstilbestrol started during the first trimester. None in the control group were so treated (p less than 0.00001).

Compares eight young cancer patients with matched controls and identifies prenatal DES exposure.

Source
Arthur L. Herbst, Howard Ulfelder, and David C. Poskanzer; New England Journal of Medicine
Date
22 April 1971
Quoted from
Abstract (N Engl J Med 1971;284:878-881)
Grade
Peer-reviewed
Document
https://www.nejm.org/doi/full/10.1056/NEJM197104222841604
Accessed
2026-11-09
Cited by
Findings citing this exhibit

Cited by

Finding MED-11.8
Peer-reviewed The 1971 DES study linked maternal treatment to vaginal cancer in daughters, and later cohorts documented additional adverse outcomes decades after prenatal exposure.