Exhibit 568

21 CFR 182.1745, Sodium carboxymethylcellulose

Exhibit 568 · Regulation

21 CFR 182.1745, Sodium carboxymethylcellulose

This substance is generally recognized as safe when used in accordance with good manufacturing practice.

FDA's GRAS list entry for sodium carboxymethylcellulose, a regulation in part 182 of title 21. The substance is listed by FDA and was not a company's own conclusion.

Source: U.S. Food and Drug Administration
Date: In force 1 November 2026 (eCFR)
Quoted from: 21 CFR 182.1745(b)
Grade: Primary record
Document: https://www.ecfr.gov/current/title-21/section-182.1745
Accessed: 2026-11-09
Cited by: Findings citing this exhibit
Note: Date and notice of the original listing not found. The Federal Register history of the listing would date it.

Cited by

Finding AGR-1.9: Peer-reviewed Sodium carboxymethylcellulose is listed in FDA's regulations as generally recognized as safe when used in accordance with good manufacturing practice (21 CFR 182.1745). In a double-blind controlled-feeding study of 16 healthy adults, 15 g per day of carboxymethylcellulose for 11 days reduced gut microbiota diversity and changed the fecal metabolome relative to controls, and the study reported no disease outcome.